A IMPORTÂNCIA DAS INCRETINAS NO TRATAMENTO DO DIABETES MELLITUS TIPO 2.

Diabetes Mellitus type 2 has become a major public health problem in the world creating the need for research and development for more effective drugs on glycolic control that have minimal adverse effects. It was observed in the nineteenth century that some factors were synthesized by the intestinal mucosa through the ingestion of foods which stimulate the release of substances produced by the pancreas which are capable of reducing glucose levels in the blood. These factors were called incretins. The incretins are hormones produced by the gastrointestinal tract and released when there is a nutrient intake on its' arrival in the intestinal tract. Their release stimulates stimulates insulin secretions that contain GIP (Gastric Inhibitory Polypeptide) and GLP-1 (the Glucagon-English likepeptide-1) hormones. For the treatment based on the new model based on the incretins, mimetic incretins have been created that are analogs and GLP-1 agonists, which exhibit similar pharmacological actions of GLP-1, reducing the levels in the glycosylated hemoglobin and postprandial glycerin. By fasting it reduces the glucagon release, allowing weight loss. [ABSTRACT FROM AUTHOR]