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Role of hypothyroidism in obstructive sleep apnea: a meta-analysis.
- Source :
-
Current Medical Research & Opinion . Jun2016, Vol. 32 Issue 6, p1059-1064. 6p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>This study evaluates the role of hypothyroidism in obstructive sleep apnea (OSA) by comparing the OSA indices in hypothyroid OSA (OSA-HYPOT) with euthyroid OSA (OSA-EUTHY) patients.<bold>Methods: </bold>After literature search in several electronic databases and selection of studies by following eligibility criteria, meta-analyses of mean differences/standardized mean differences were performed to compare OSA indices at the time of diagnosis between OSA-HYPOT and OSA-EUTHY patients. Metaregression analyses were carried out to examine the relationship between age, BMI, sample size, and gender vs OSA indices in OSA-HYPOT patients.<bold>Results: </bold>Twelve studies and five case reports recruiting 192 OSA-HYPOT and 1423 OSA-EUTHY patients were included in the meta-analysis. Prevalence (mean ± SD) of clinical hypothyroidism in OSA patients was 8.12 ± 7.13% and that of subclinical hypothyroidism 11.07 ± 8.49%. Apnea-Hypopnea Index, time of sleep with oxygen desaturation <90%, and Epworth Sleepiness Scale were significantly higher in the OSA-HYPOT patients at diagnosis, whereas there was no significant difference in arousal index, respiratory disturbance index and sleeping efficiency between OSA-HYPOT and OSA-EUTHY patients. Body mass index was positively associated with Apnea-Hypopnea Index in OSA-HYPOT patients.<bold>Conclusions: </bold>Hypothyroidism is found to be associated with severity of OSA. However, obesity can be a confounder in the outcomes observed herein. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03007995
- Volume :
- 32
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Current Medical Research & Opinion
- Publication Type :
- Academic Journal
- Accession number :
- 116267857
- Full Text :
- https://doi.org/10.1185/03007995.2016.1157461