Nine new compounds from the whole plants of Rehmannia chingii.

Nine new compounds, together with 16 known analogs, were isolated from the whole plants ofRehmannia chingii. The structures of compounds1–9were elucidated on the basis of their spectroscopic data and chemical evidence. In addition, the new compounds were tested for their hepatoprotective activities against APAP-induced HepG2 cell damage and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line. Compounds2and5exhibited pronounced hepatoprotective activities against APAP-induced HepG2 cell damage at a concentration of 10 μM, and compounds4and9showed moderate inhibitory activity against microglial inflammation factor with IC50values of 3.51 and 7.11 μM, respectively. [ABSTRACT FROM PUBLISHER]