Análisis predictivo de la profundidad del tratamiento fotodinámico con nanoportadoras de diferentes fotosensibilizadoresr.

The effect of gold nanoparticles to deliver different types of photosensitizer used in Photodynamic Therapy on the depth of light penetration is studied by means of a predictive model with dosimetric purposes. The model employed allows to analyze the changes induced by the spherical nanoparticles administration in the optical distribution within the malignant tissue. The depth of photodynamic treatment was estimated in a nodular basal cell carcinoma taking into account both the conventional photosensitizer delivery and by means of nanoparticles. Significant differences were observed and demonstrate the great functionality of predictive modeling to rule out the use of certain nanoparticles to deliver the photosensitizer due to the limited therapeutic effect at certain depths within the carcinoma despite the photosensitizer delivery improvements. [ABSTRACT FROM AUTHOR]