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Synthesis and antiproliferative activity of D-ring substituted steroidal benzamidothiazoles.
- Source :
-
Steroids . Aug2016, Vol. 112, p103-108. 6p. - Publication Year :
- 2016
-
Abstract
- Using progesterone as the starting material, we synthesized a series of steroidal derivatives possessing a D-ring substituted benzamidothiazole. All of the final structures were reported and identified by NMR and HRMS spectrometry for the first time. The antiproliferative activity of the synthesized compounds against PC-3 (human prostate cancer cell line) and SKOV-3 (ovarian cancer cells) were investigated. The preliminary results showed that compounds 8b , 8d and 8g possessed moderate antiproliferative activities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0039128X
- Volume :
- 112
- Database :
- Academic Search Index
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 116575492
- Full Text :
- https://doi.org/10.1016/j.steroids.2016.04.009