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Kaposi's sarcoma in AIDS: basement membrane and endothelial cell markers in late-stage lesions.

Authors :
Green, T. L.
Meyer, J. R.
Daniels, T. E.
Greenspan, J. S.
De Souza, V.
Kramer, R. H.
Source :
Journal of Oral Pathology. Jul88, Vol. 17 Issue 6, p266-272. 7p.
Publication Year :
1988

Abstract

Early-stage lesions of Kaposi's sarcoma (KS) are composed of single-layered, highly flattened cells lining collagen bundles, whereas late-stage lesions contain densely packed, spindle-shaped cells. We examined the progression of KS lesions in oral mucosa and lymph nodes from patients with AIDS, using antibodies specific for blood vascular endothelial cells (Factor VIII-related antigen) and their basement membrane (Type IV collagen and laminin). In addition, the plant lectin Ulex europaeus, which selectively stains blood vessels, was also used. In early-stage KS lesions, fibronectin, laminin and Type IV collagen were co-distributed at the interface between KS cells and collagen bundles; Factor VIII-related antigen and Ulex europaeus lectin staining was present in vascular channels and in the KS cells. However, in late-stage lesions, few if any KS cells stained with antibody to Factor VIII-associated antigen, although endothelial cells lining blood vessels were positive. Strong staining for laminin and Type IV collagen was present in a pericellular pattern throughout the nodular late-stage lesions. Since lymphatic capillary endothelium does not produce basement-membrane-specific macromolecules, these results support the conclusion that KS cells are related to blood vascular endothelium but eventually lose certain endothelium-specific markers as the cells are transformed into the spindle-shaped cell type. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009777
Volume :
17
Issue :
6
Database :
Academic Search Index
Journal :
Journal of Oral Pathology
Publication Type :
Academic Journal
Accession number :
11658895
Full Text :
https://doi.org/10.1111/j.1600-0714.1988.tb01535.x