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Associations of body mass index with cancer incidence among populations, genders, and menopausal status: A systematic review and meta-analysis.
- Source :
-
Cancer Epidemiology . Jun 2016, Vol. 42, p1-8. 8p. - Publication Year :
- 2016
-
Abstract
- In order to further reveal the differences of association between body mass index (BMI) and cancer incidence across populations, genders, and menopausal status, we performed comprehensive meta-analysis with eligible citations. The risk ratio (RR) of incidence at 10 different cancer sites (per 5kg/m(2) increase in BMI) were quantified separately by employing generalized least-squares to estimate trends, and combined by meta-analyses. We observed significantly stronger association between increased BMI and breast cancer incidence in the Asia-Pacific group (RR 1.18:1.11-1.26) than in European-Australian (1.05:1.00-1.09) and North-American group (1.06:1.03-1.08) (meta-regression p<0.05). No association between increased BMI and pancreatic cancer incidence (0.94:0.71-1.24) was shown in the Asia-Pacific group (meta-regression p<0.05), whereas positive associations were found in other two groups. A significantly higher RR in men was found for colorectal cancer in comparison with women (meta-regression p<0.05). Compared with postmenopausal women, premenopausal women displayed significantly higher RR for ovarian cancer (pre- vs. post-=1.10 vs. 1.01, meta-regression p<0.05), but lower RR for breast cancer (pre- vs. post-=0.99 vs. 1.11, meta-regression p<0.0001). Our results indicate that overweight or obesity is a strong risk factor of cancer incidence at several cancer sites. Genders, populations, and menopausal status are important factors effecting the association between obesity and cancer incidence for certain cancer types. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18777821
- Volume :
- 42
- Database :
- Academic Search Index
- Journal :
- Cancer Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 116661111
- Full Text :
- https://doi.org/10.1016/j.canep.2016.02.010