FLT3 (CD135) and Interleukin-2 receptor alpha-chain (CD25) expression in acute myeloid leukemia: improving the correspondence to FLT3 - internal tandem duplication mutation.

Authors :: Abd El‐Ghaffar, A. A.
El‐Gamal, R. A.
Mostafa, N. N.
Abou Shady, N. M.
Source :: International Journal of Laboratory Hematology. Aug2016, Vol. 38 Issue 4, pe69-e72. 4p.
Publication Year :: 2016
Abstract: In this article, the authors analyzed FMS-like tyrosine kinase 3 (FLT3), internal tandem duplication (ITD) related markers and CD135 and CD25, using flow cytometry. Topics discussed include FLT3 gene mutation found to determine acute myeloid leukemia (AML) prognosis and predict poor outcome; AML-related cytogenetic abnormalities detected in 31 patients; and no significant difference in CD135 or CD25 values across the genetic prognostic groups.

Subjects :: *ACUTE myeloid leukemia
*CHI-squared test
*CYTOGENETICS
*FLOW cytometry
*IMMUNOPHENOTYPING
*INTERLEUKIN-2
*MULTIVARIATE analysis
*GENETIC mutation
*POLYMERASE chain reaction
*STATISTICS
*TRANSFERASES
*CD4 antigen
*GENETIC markers
*DATA analysis
*RECEIVER operating characteristic curves
*MANN Whitney U Test
*ONE-way analysis of variance
*GENETICS

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