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Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma.
- Source :
-
BMC Cancer . 7/11/2016, Vol. 16, p1-8. 8p. 1 Color Photograph, 4 Charts, 3 Graphs. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily. PPARγ is essential in adipocyte differentiation from precursor cells. Its antitumorigenic effects are reported in certain malignancies; however, its effects in liposarcoma are unclear.<bold>Methods: </bold>We analyzed PPARγ expression using immunohistochemistry (IHC) in 46 patients with myxoid liposarcoma [MLS; median age, 47 years (range, 14-90 years) and mean follow-up period, 91 months (range, 13-358 months)]. PPARγ mRNA expression levels were measured by quantitative reverse transcription polymerase chain reaction. Further, we evaluated the correlation of PPARγ expression with clinical outcomes.<bold>Results: </bold>We found that the metastasis-free survival rate was significantly higher in lower PPARγ expressers [34 patients with labeling index (LI) <50 %] than in higher expressers (12 patients with LI ≥50 %; p = 0.01). Cox multivariate analysis revealed that a higher PPARγ level was an independent predictor of metastasis (relative risk = 6.945, p = 0.026). Furthermore, using 28 fresh MLS specimens, we confirmed an increased PPARγ mRNA expression level in the higher LI group (p = 0.001).<bold>Conclusions: </bold>In this study, higher PPARγ expression in MLS was a risk factor associated with distant metastasis; therefore, it would be a novel prognostic marker for MLS. Further analyses will help to understand the correlation between PPARγ expression and tumor malignancy in liposarcoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPOSARCOMA
*PGC-1 protein
*TRANSCRIPTION factors
*NUCLEAR receptors (Biochemistry)
*IMMUNOHISTOCHEMISTRY
*POLYMERASE chain reaction
*MULTIVARIATE analysis
*PATIENTS
*PROTEIN metabolism
*RNA metabolism
*CANCER relapse
*LONGITUDINAL method
*SOFT tissue tumors
*SURVIVAL
*RETROSPECTIVE studies
*REVERSE transcriptase polymerase chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 16
- Database :
- Academic Search Index
- Journal :
- BMC Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 116795048
- Full Text :
- https://doi.org/10.1186/s12885-016-2524-6