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T-cell receptor gene analysis in cutaneous T-cell lymphomas.
- Source :
-
Clinical & Experimental Dermatology . Mar1996, Vol. 21 Issue 2, p81-87. 7p. - Publication Year :
- 1996
-
Abstract
- An essential property of the immune system is its ability to generate diverse antibody and T-cell mediated responses to virtually any potential foreign particle. The basic molecular mechanisms responsible for producing this extensive diversity have now been elucidated. Each T cell expresses a unique membrane bound T-cell antigen receptor (TCR) which combines with specific antigenic peptides and major histocompatibility complex molecules. The characterization of TCR usage now represents a focal point for many studies of inflammatory and neoplastic disorders. Such studies are helping to clarify the pathogenesis of T-cell mediated diseases and provide the basis for the development of specific therapies. This paper will review several techniques used to identify neoplastic T-cell clones in cutaneous T-cell lymphoma. Similar methods may be used to analyse TCR gene usage in cutaneous inflammatory dermatoses. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T-cell receptor genes
*LYMPHOMAS
*IMMUNE system
*T cells
*PEPTIDES
*SKIN diseases
Subjects
Details
- Language :
- English
- ISSN :
- 03076938
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 11683684
- Full Text :
- https://doi.org/10.1111/j.1365-2230.1996.tb00025.x