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Droplet organelles?
- Source :
-
EMBO Journal . 8/1/2016, Vol. 35 Issue 15, p1603-1612. 10p. - Publication Year :
- 2016
-
Abstract
- Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by lipid bilayers. These compartments are implicated in a wide range of cellular activities, and they have been variously described as bodies, granules, or organelles. Recent evidence suggests that a liquid-liquid phase separation ( LLPS) process may drive their formation, possibly justifying the unifying term 'droplet organelle'. A veritable deluge of recent publications points to the importance of low-complexity proteins and RNA in determining the physical properties of phase-separated structures. Many of the proteins linked to such structures are implicated in human diseases, such as amyotrophic lateral sclerosis ( ALS). We provide an overview of the organizational principles that characterize putative 'droplet organelles' in healthy and diseased cells, connecting protein biochemistry with cell physiology. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02614189
- Volume :
- 35
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- EMBO Journal
- Publication Type :
- Academic Journal
- Accession number :
- 117124095
- Full Text :
- https://doi.org/10.15252/embj.201593517