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Synthesis of bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4-diones and evaluation of their antibacterial and antifungal activities.
- Source :
-
Journal of Fluorine Chemistry . Aug2016, Vol. 188, p191-195. 5p. - Publication Year :
- 2016
-
Abstract
- A series of 5,5-bis(trifluoromethyl)-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1 H ,3 H )-diones has been prepared by the cyclocondensation of N -acylimines of hexafluoroacetone and 6-aminouracils. The obtained compounds were screened for their activities against Gram-positive ( Staphylococcus aureus, Staphylococcus epidermidis and Bacillus anthracis ) and Gram-negative ( Escherichia coli ) bacteria, as well as fungus Candida albicans. A few of the title compounds showed promising antimicrobial activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221139
- Volume :
- 188
- Database :
- Academic Search Index
- Journal :
- Journal of Fluorine Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 117159064
- Full Text :
- https://doi.org/10.1016/j.jfluchem.2016.06.019