Back to Search
Start Over
Functional regulatory roles of microRNAs in atherosclerosis.
- Source :
-
Clinica Chimica Acta . Sep2016, Vol. 460, p164-171. 8p. - Publication Year :
- 2016
-
Abstract
- MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3′UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a complex disease, atherosclerosis is influenced by a combination of multiple genes and environmental factors. Both of them play a role in atherogenesis by affecting different types of cells (such as endothelial cell, vascular smooth muscle cell and monocyte/macrophage) function. MicroRNAs control the senescence and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, and macrophage-driven cytokine production and polarization. By these effects, microRNAs can influence the processes of atherosclerosis and may represent new molecular targets for therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 460
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 117267652
- Full Text :
- https://doi.org/10.1016/j.cca.2016.06.044