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Systematic Review of Health-Related Quality of Life in Patients with Pulmonary Arterial Hypertension.
- Source :
-
PharmacoEconomics . Aug2016, Vol. 34 Issue 8, p751-770. 20p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>The increasing survival of patients with pulmonary arterial hypertension (PAH) has shifted attention towards the disease burden that PAH imposes on patients and healthcare systems. Most studies emphasize epidemiology and medications, while large observational studies reporting on the health-related quality of life (HRQOL) of patients with PAH are lacking.<bold>Objective: </bold>Our objective was to study the HRQOL of patients with PAH and to summarize the factors that influence it.<bold>Methods: </bold>We conducted systematic literature searches in English (PubMed, Web of Knowledge, ScienceDirect and OVID) and Chinese (China National Knowledge Infrastructure, Wanfang Data, Chongqing VIP and SinoMed) databases to identify studies published from 2000 to 2015 assessing the HRQOL of patients with PAH. Search results were independently reviewed and extracted by two reviewers.<bold>Results: </bold>Of 3392 records identified in the initial search, 20 eligible papers (19 English, 1 Chinese) were finally included. Studies used a range of instruments; the generic 36-item Short Form Survey (SF-36) was the most widely used, and the disease-specific Cambridge Pulmonary Hypertension Outcome Survey (CAMPHOR) was the second mostly widely used. Mean HRQOL scores assessed via the SF-36 (physical component summary [PCS] 25.4-80.1; mental component summary [MCS] 33.2-76.0) and CAMPHOR (symptom scores 3.1-17; total HRQOL 2.8-12.6; activity scores 3.8-18.1) varied across studies, reporting decreased HRQOL in patients. Mental health (depression, anxiety, stress), physical health (exercise capacity, symptoms) and medical therapies were reported to affect HRQOL.<bold>Conclusion: </bold>We found that PAH places a substantial burden on patients, particularly in terms of HRQOL; however, the paucity of large observational studies in this area requires the attention of researchers, especially in China. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11707690
- Volume :
- 34
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- PharmacoEconomics
- Publication Type :
- Academic Journal
- Accession number :
- 117355256
- Full Text :
- https://doi.org/10.1007/s40273-016-0395-y