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A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models.
- Source :
-
Trends in Biotechnology . Sep2016, Vol. 34 Issue 9, p757-769. 13p. - Publication Year :
- 2016
-
Abstract
- We discuss the current challenges and future prospects of flow-based organoid models and 3D self-assembling scaffolds. The existing paradigm of 3D culture suffers from a lack of control over organoid size and shape; can be an obstacle for cell harvesting and extended cellular and molecular analysis; and does not provide access to the function of exocrine glands. Moreover, existing organ-on-chip models are mostly composed of 2D extracellular matrix (ECM)-coated elastomeric membranes that do not mimic real organ architectures. A new comprehensive 3D toolbox for cell biology has emerged to address some of these issues. Advances in microfabrication and cell-culturing approaches enable the engineering of sophisticated models that mimic organ 3D architectures and physiological conditions, while supporting flow-based drug screening and secretomics-based diagnosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01677799
- Volume :
- 34
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Trends in Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 117436326
- Full Text :
- https://doi.org/10.1016/j.tibtech.2016.06.012