Back to Search
Start Over
One-pot synthesis and theoretical calculation for trifluoromethylated pyrrolizidines by 1,3-dipolar cycloaddition with azomethine ylides and β-trifluoromethyl acrylamides.
- Source :
-
Journal of Fluorine Chemistry . Sep2016, Vol. 189, p22-32. 11p. - Publication Year :
- 2016
-
Abstract
- The reaction with β-trifluoromethyl acrylamide 3e and azomethine ylides generated from l -proline and several aldehydes provided the corresponding trifluoromethylated pyrrolizidines with excellent diastereoselectivity (>20/1) in all cases and moderate regioselectivity (up to 1/5.9). A DFT calculation was also examined to reveal the origin of these stereoselectivities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221139
- Volume :
- 189
- Database :
- Academic Search Index
- Journal :
- Journal of Fluorine Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 117583814
- Full Text :
- https://doi.org/10.1016/j.jfluchem.2016.07.013