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Multi-residue determination of 210 drugs in pork by ultra-high-performance liquid chromatography–tandem mass spectrometry.
- Source :
-
Journal of Chromatography A . Sep2016, Vol. 1463, p49-59. 11p. - Publication Year :
- 2016
-
Abstract
- This paper presents a multi-residue analytical method for 210 drugs in pork using ultra-high-performance liquid chromatography-Q-Trap tandem mass spectrometry (UPLC–MS/MS) within 20 min via positive ESI in scheduled multi-reaction monitoring (MRM) mode. The 210 drugs, belonging to 21 different chemical classes, included macrolides, sulfonamides, tetracyclines, β-lactams, β-agonists, aminoglycosides, antiviral drugs, glycosides, phenothiazine, protein anabolic hormones, non-steroidal anti-inflammatory drugs (NSAIDs), quinolones, antifungal drugs, corticosteroids, imidazoles, piperidines, piperazidines, insecticides, amides, alkaloids and others. A rapid and simple preparation method was applied to process the animal tissues, including solvent extraction with an acetonitrile/water mixture (80/20, v/v), defatting and clean-up processes. The recoveries ranged from 52% to 130% with relative standard deviations (RSDs) < 20% for spiked concentrations of 10, 50 and 250 μg/kg. More than 90% of the analytes achieved low limits of quantification (LOQs) < 10 μg/kg. The decision limit (CCα), detection capability (CCβ) values were in the range of 2–502 μg/kg and 4–505 μg/kg, respectively. This method is significant for food safety monitoring and controlling veterinary drug use. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1463
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 117617664
- Full Text :
- https://doi.org/10.1016/j.chroma.2016.08.001