Cyclization of trifluoro- N-(prop-2-yn-1-yl)methanesulfonamides to N-(hydroxymethyl)-1,2,3-triazoles.

Three-component heterocyclizations of trifluoro- N-(prop-2-yn-1-yl)methanesulfonamide, trifluoro- N-pheny- N-(prop-2-yn-1-yl)methanesulfonamide, and trifluoro- N, N-di(prop-2-yn-1-yl)methanesulfonamide with formaldehyde and sodium azide afforded N-{[2-(hydroxymethyl)-2 H-1,2,3-triazol-4-yl]methyl}-, N-{[2-(hydroxymethyl)-2 H-1,2,3-triazol-4-yl]methyl}- N-phenyl-, and N, N-bis{[2-(hydroxymethyl)-2 H-1,2,3-triazol-4-yl]methyl}trifluoromethanesulfonamides as the major products together with minor 1-(hydroxymethyl)-1 H-1,2,3-triazole isomers. [ABSTRACT FROM AUTHOR]