Back to Search Start Over

Impact of Valve Surgery on 6-Month Mortality in Adults With Complicated, Left-Sided Native Valve Endocarditis: A Propensity Analysis.

Authors :
Vikram, Holenarasipur R.
Buenconsejo, Joan
Hasbun, Rodrigo
Quagliarello, Vincent J.
Source :
JAMA: Journal of the American Medical Association. 12/24/2003, Vol. 290 Issue 24, p3207-3214. 8p.
Publication Year :
2003

Abstract

Context: Complicated, left-sided native valve endocarditis causes significant morbidity and mortality in adults. The presumed benefits of valve surgery remain unproven due to lack of randomized controlled trials. Objective: To determine whether valve surgery is associated with reduced mortality in adults with complicated, left-sided native valve endocarditis. Design and Setting: Retrospective, observational cohort study conducted from January 1990 to January 2000 at 7 Connecticut hospitals. Propensity analyses were used to control for bias in treatment assignment and prognostic imbalances. Patients: Of the 513 adults with complicated, left-sided native valve endocarditis, 230 (45%) underwent valve surgery and 283 (55%) received medical therapy alone. Main Outcome Measure: All-cause mortality at 6 months after baseline. Results: In the 6-month period after baseline, 131 patients (26%) died. In unadjusted analyses, valve surgery was associated with reduced mortality (16% vs 33%; hazard ratio [HR], 0.43; 95% confidence interval [CI], 0.29-0.63; P<.001). After adjustment for baseline variables associated with mortality (including hospital site, comorbidity, congestive heart failure, microbial etiology, immunocompromised state, abnormal mental status, and refractory infection), valve surgery remained associated with reduced mortality (adjusted HR, 0.35; 95% CI, 0.23-0.54; P<.02). In further analyses of 218 patients matched by propensity scores, valve surgery remained associated with reduced mortality (15% vs 28%; HR, 0.45; 95% CI, 0.23-0.86; P = .01). After additional adjustment for variables that contribute to heterogeneity and confounding within the propensity-matched group, surgical therapy remained significantly associated with a lower mortality (HR, 0.40; 95% CI, 0.18-0.91; P = .03). In this propensity-matched group, patients with moderate to severe congestive heart failure showed the greatest reduction in mortality with valve surgery (14% vs 51%; HR, 0.22; 95% C... [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00987484
Volume :
290
Issue :
24
Database :
Academic Search Index
Journal :
JAMA: Journal of the American Medical Association
Publication Type :
Academic Journal
Accession number :
11768402
Full Text :
https://doi.org/10.1001/jama.290.24.3207