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The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease.

The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease.

Authors :
Zamparelli, Marco Sanduzzi
Compare, Debora
Coccoli, Pietro
Rocco, Alba
Nardone, Olga Maria
Marrone, Giuseppe
Gasbarrini, Antonio
Grieco, Antonio
Nardone, Gerardo
Miele, Luca
Source :
International Journal of Molecular Sciences. Aug2016, Vol. 17 Issue 8, p1225. 11p. 1 Diagram.
Publication Year :
2016

Abstract

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
17
Issue :
8
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
117692137
Full Text :
https://doi.org/10.3390/ijms17081225