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Tricarbonylrhenium(i) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer.
- Source :
-
New Journal of Chemistry . Sep2016, Vol. 40 Issue 9, p7379-7387. 9p. - Publication Year :
- 2016
-
Abstract
- Complexes [ReCl(CO)3(H2AcPh)] (1), [ReCl(CO)3(H2AcpClPh)]·0.5C7H8 (2) and [ReCl(CO)3(H2AcpNO2Ph)]·0.5C7H8 (3) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its para-chlorophenylhydrazone (H2AcpClPh) and para-nitrophenylhydrazone (H2AcpNO2Ph) analogues. Coordination to tricarbonylrhenium(i) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (2) and (3) induced apoptosis on NCI-H460 cells. Complex (2) induced mitochondrial damage while treatment with 3 showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (2) and (3) showed a high antioxidant activity, 2 being more potent in reducing intracellular reactive oxygen species (ROS) production. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER cell culture
*CELLULAR pathology
*APOPTOSIS
*CELL death
*APOPTIN
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 40
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 117776126
- Full Text :
- https://doi.org/10.1039/c6nj00050a