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Ideal glycated hemoglobin cut-off points for screening diabetes and prediabetes in a Chinese population.
- Source :
-
Journal of Diabetes Investigation . Sep2016, Vol. 7 Issue 5, p695-702. 8p. - Publication Year :
- 2016
-
Abstract
- Aims/Introduction The aims of the present study were to evaluate the diagnostic value of fasting plasma glucose, 2-h postload plasma glucose and glycosylated hemoglobin (HbA1c) measurements in the screening of diabetes and prediabetes, and to determine the cut-off point of HbA1c in the diagnosis of diabetes and prediabetes in a Chinese population. Materials and Methods A total of 7,611 individuals aged 40 years or older, who did not have a prior history of diabetes, were randomly selected in the Changchun area. For each participant, a questionnaire was completed, and a physical examination and an oral glucose tolerance test were carried out. The values of fasting plasma glucose, 2-h postload plasma glucose and HbA1c were compared by area under the receiver operating characteristic curves. The Youden index was used to identify the optimal cut-off point of HbA1c in the diagnosis of diabetes and prediabetes. Results The prevalence of newly diagnosed diabetes and prediabetes was 12.71% and 29.39%, respectively. In participants with newly diagnosed diabetes, the area under the receiver operating characteristic curve was 0.8368 for fasting plasma glucose, 0.9330 for 2-h postload plasma glucose and 0.8064 for HbA1c; whereas for prediabetes, these values were 0.8022, 0.9288 and 0.6895, respectively. In addition, an HbA1c threshold of 6.3% showed the highest Youden index (0.4799) for detecting diabetes; furthermore, an HbA1c threshold of 5.8% showed the highest Youden index (0.2866) for detecting prediabetes. Conclusions HbA1c ≥6.3% (45 mmol/mol) and between 5.8% and 6.2% (40-44 mmol/mol) were the optimal cut-off values for the diagnosis of diabetes and prediabetes, respectively, in a Chinese population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20401116
- Volume :
- 7
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 117807884
- Full Text :
- https://doi.org/10.1111/jdi.12498