Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride.

Authors :: Haili Liao
Aimin Li
Xingsong Chen
Kun Liang
Yang Shen
Qingfeng Liang
Kewei Xu
Shore, Daniel G. M.
Villemure, Elisia
Siu, Michael
Huestis, Malcolm P.
Source :: Synlett. 2016, Vol. 27 Issue 15, p2251-2253. 3p.
Publication Year :: 2016
Abstract: A batchwise, multigram preparation of 2-azabicyclo- [2.1.1]hexane hydrochloride (1·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert-butylsulfinamide to forge the [2.1.1]-bicyclic ring system. [ABSTRACT FROM AUTHOR]