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Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation.
- Source :
-
Developmental Cell . Sep2016, Vol. 38 Issue 5, p453-462. 10p. - Publication Year :
- 2016
-
Abstract
- Summary Blood neutrophils perform an essential host-defense function by directly migrating to bacterial invasion sites to kill bacteria. The mechanisms mediating the transition from the migratory to bactericidal phenotype remain elusive. Here, we demonstrate that TRPM2, a trp superfamily member, senses neutrophil-generated reactive oxygen species and restrains neutrophil migration. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition. The oxidant sensing-induced termination of neutrophil migration at the site of infection permits a smooth transition to the subsequent microbial killing phase. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15345807
- Volume :
- 38
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Developmental Cell
- Publication Type :
- Academic Journal
- Accession number :
- 117916273
- Full Text :
- https://doi.org/10.1016/j.devcel.2016.07.014