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Kinetic Study on Aminolysis of O-2-Pyridyl Thionobenzoate in Acetonitrile: Effect of Changing Electrophilic Center from CO to CS on Reactivity and Reaction Mechanism.
- Source :
-
Bulletin of the Korean Chemical Society . Sep2016, Vol. 37 Issue 9, p1401-1405. 5p. - Publication Year :
- 2016
-
Abstract
- Pseudo-first-order rate constants ( kobsd) for nucleophilic substitution reaction of O-2-pyridyl thionobenzoate ( 7) with a series of secondary amines in MeCN at 25.0 ± 0.1°C have been measured spectrophotometrically. The plots of kobsd vs. [amine] curve upward, indicating that the reaction proceeds through a stepwise mechanism with a zwitterionic tetrahedral intermediate (T±), which decomposes to the products through uncatalyzed and catalyzed routes. It has been proposed that the uncatalyzed reaction proceeds through a six-membered cyclic transition state ( TS), in which expulsion of the leaving group occurs in the rate-determining step. The catalyzed reaction from T± proceeds through a concerted mechanism with a six-membered cyclic TS rather than via a stepwise pathway with an anionic intermediate T−. This is in contrast to the report that the corresponding reaction of 2-pyridyl benzoate ( 6, a CO analogue of 7) proceeds through a forced concerted mechanism. Comparison of the second-order rate constants for the uncatalyzed reaction of 7 with those reported previously for the corresponding reaction of 6 has revealed that 7 is much more reactive than 6. Factors that affect the reactivity and reaction mechanism are discussed in detail. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02532964
- Volume :
- 37
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bulletin of the Korean Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 117925508
- Full Text :
- https://doi.org/10.1002/bkcs.10875