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Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery.
- Source :
-
Hypertension in Pregnancy . Aug2016, Vol. 35 Issue 3, p394-404. 11p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery.<bold>Methods: </bold>A matched case-control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32).<bold>Results: </bold>PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL.<bold>Conclusion: </bold>Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 117954803
- Full Text :
- https://doi.org/10.3109/10641955.2016.1162315