Biomathematical modeling on chronobiological rhythms of antibody- exemplified through chicken IgY.

The immune system of all living things shows regularly recurring rhythmic variations in numerous frequencies. The responses of the immune system to an antigen entry could vary in accordance to the chronobiological phenomena. These cyclic oscillations in living things occur for many essential biological processes in order to deal with environmental changes and challenges. This study aimed to develop mathematical models with important physiological parameters involving immune response for antibody rhythms using the circadian, infradian, and ultradian rhythms of IgY antibody from our earlier experimental findings, such as the model of circadian rhythm:. These models could be used in many aspects, for instance, to explain the controversies concerning antibody concentration with biological reasons and mathematical calculations, to optimize the antibody yield in large-scale production. In general, this approach could be extended to construct computational models for other antibodies using their biological rhythms to describe their physiological and pathophysiological mechanisms. This approach would aid to utilize the engineered antibodies and their derivatives for various biomedical applications. [ABSTRACT FROM PUBLISHER]