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Synthesis and evaluation of a 68Ga labeled folic acid derivative for targeting folate receptors.

Authors :
Jain, Akanksha
Mathur, Anupam
Pandey, Usha
Bhatt, Jyotsna
Mukherjee, Archana
Ram, Ramu
Sarma, Haladhar Dev
Dash, Ashutosh
Source :
Applied Radiation & Isotopes. Oct2016, Vol. 116, p77-84. 8p.
Publication Year :
2016

Abstract

Present work evaluates the potential of a newly synthesized 68 Ga-NOTA-folic acid conjugate for PET imaging of tumors over-expressing folate receptors (FRs). NOTA-folic acid conjugate was synthesized and characterized. It was radiolabeled with 68 Ga in ≥ 95% radiolabeling yields. In vitro cell binding studies showed a maximum cell uptake of 1.7±0.4% per million KB cells which was completely blocked on addition of cold folic acid showing specificity towards the FRs. However, further studies in tumor xenografts are warranted in order to assess the potential of 68 Ga-folic acid complex for imaging tumors over-expressing FRs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09698043
Volume :
116
Database :
Academic Search Index
Journal :
Applied Radiation & Isotopes
Publication Type :
Academic Journal
Accession number :
118027339
Full Text :
https://doi.org/10.1016/j.apradiso.2016.07.024