右美托咪定对重型颅脑损伤患者术后持续镇静的效果 及脑组织的保护作用

Objective: To explore the continuous sedation and brain protective effect of dexmedetomidine severe craniocerebral injury patients after operation. Methods: A total of 90 cases of severe craniocerebral injury patients treated in hospital from July 2013 to July 2015 were randomly divided into observation group 45 cases and control group 45 cases, patients in the control group were given fentanyl general anesthesia, while the patients in the observation group were given Dex anesthesia. The changes of S-100β protein, MAP,PCO2, SpO2, HR and cerebral oxygen metabolism indexes at different time points were compared. Results: There were no significant differences in Ca-jv DO2, CERO2 and Sjv O2 between the two groups before and after operation(P>0.05). From T1~T4, the MAP and HR significantly decreased in observation group, and compared with T0 the difference with statistically significant(P < 0.05), and the MAP and HR in observation group were significantly lower than those in the control group in same period(P < 0.05). From T1~T4, serum S-100βincreased in the two groups, which was significantly higher than that of T0(P < 0.05), and the observation group was significantly lower than that of the control group in same period(P < 0.05). Conclusion: Postoperative continuous intravenous infusion of dexmedetomidine had sedative and analgesic effects for severe craniocerebral injury patients, and in a certain extent protected the brain tissue. [ABSTRACT FROM AUTHOR]