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Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory.
- Source :
-
Clinical Neurophysiology . Oct2016, Vol. 127 Issue 10, p3252-3258. 7p. - Publication Year :
- 2016
-
Abstract
- Objective Epilepsy is characterized by unpredictable and sudden paroxysmal neuronal firing occurrences and sometimes evolving in clinically evident seizure. To predict seizure event, small-world characteristic in nine minutes before seizure, divided in three 3-min periods (T0, T1, T2) were investigated. Methods Intracerebral recordings were obtained from 10 patients with drug resistant focal epilepsy examined by means of stereotactically implanted electrodes; analysis was focused in a period of low spiking (Baseline) and during two seizures. Networks’ architecture is undirected and weighted. Electrodes’ contacts close to epileptic focus are the vertices, edges are weighted by mscohere (=magnitude squared coherence). Results Differences were observed between Baseline and T1 and between Baseline and T2 in theta band; and between Baseline and T1, Baseline and T2, and near-significant difference between T0 and T2 in Alpha 2 band. Moreover, an intra-band index was computed for small worldness as difference between Theta and Alpha 2. It was found a growing index trend from Baseline to T2. Conclusions Cortical network features a specific pre-seizure architecture which could predict the incoming epileptic seizure. Significance Through this study future researches could investigate brain connectivity modifications approximating a clinical seizure also in order to address a preventive therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13882457
- Volume :
- 127
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 118077438
- Full Text :
- https://doi.org/10.1016/j.clinph.2016.07.006