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Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis.

Authors :
Xianbao Zhan
Fan Wang
Yan Bi
Baoan Ji
Source :
American Journal of Physiology: Gastrointestinal & Liver Physiology. Sep2016, Vol. 311 Issue 3, pG343-G355. 13p.
Publication Year :
2016

Abstract

Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01931857
Volume :
311
Issue :
3
Database :
Academic Search Index
Journal :
American Journal of Physiology: Gastrointestinal & Liver Physiology
Publication Type :
Academic Journal
Accession number :
118092316
Full Text :
https://doi.org/10.1152/ajpgi.00372.2015