Back to Search
Start Over
Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions.
- Source :
-
Angewandte Chemie . 9/26/2016, Vol. 128 Issue 40, p12468-12472. 5p. - Publication Year :
- 2016
-
Abstract
- An enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon-nitrogen bond asymmetrically. The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as β3-amino-acid derivatives. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINATION
*CARBENES
*NITROGEN
*HYDRAZINE
*NUCLEOPHILES
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 128
- Issue :
- 40
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 118196409
- Full Text :
- https://doi.org/10.1002/ange.201606571