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Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions.
- Source :
-
Molecules . Sep2016, Vol. 21 Issue 9, p1232. 10p. 5 Diagrams, 2 Charts, 1 Graph. - Publication Year :
- 2016
-
Abstract
- Saikosaponin (SS) A is a compound with various pharmacological properties and is easily degraded into SS-B1 and SS-G under acid conditions. In the present work, two new degradation products of SS-A, formed under acid hydrolytic conditions, were detected and isolated using analytical and semi-preparative liquid chromatography technology; furthermore, their structures were characterized as hydroxy-saikosaponin A and SS-B2 by spectral analysis, which is not only essential in stability-indicating method development and validation, but also could be used as a worst case scenario to assess the analytical method performance of SS-A. Moreover, their structural transformation pathways are also proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 21
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 118209113
- Full Text :
- https://doi.org/10.3390/molecules21091232