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Three-month treatment with ulipristal acetate prior to laparoscopic myomectomy of large uterine myomas: a retrospective study.
- Source :
-
European Journal of Obstetrics & Gynecology & Reproductive Biology . Oct2016, Vol. 205, p43-47. 5p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>To assess the usefulness of 3-month treatment with ulipristal acetate (UPA) before laparoscopic myomectomy of large uterine myomas.<bold>Study Design: </bold>This retrospective analysis of a prospectively collected database included women of reproductive age requiring laparoscopic myomectomy with the following characteristics: FIGO type 3, 4 or 5 myomas; largest diameter of the main myoma ≥10cm; number of myomas ≤3; largest diameters of the other myomas ≤5cm (second myoma) and ≤3cm (third myoma). Patients either underwent direct surgery (group S) or were treated before surgery with UPA for 3 months (group UPA).<bold>Results: </bold>The mean (±SD) intraoperative blood loss was lower in group UPA (507.1±214.9ml) than in group S (684.2±316.8; p=0.012). The total operative time was lower in group UPA (137.6±26.8min) than in group S (159.7±26.8min; p<0.001); there was no significant difference in the suturing time between the two study groups (p=0.076). Hemoglobin drop was lower in group UPA (1.1±0.5g/dl) than in group S (1.3±0.7g/dl; p=0.034). Six patients in group S and no patient in group UPA required postoperative blood transfusions (p=0.031). Complications were not different between the two groups (p=0.726). Moreover, preoperative treatment with UPA caused a significant increase in hemoglobin levels (11.9±1.6g/dl) compared with baseline (9.1±1.1g/dl; p<0.001).<bold>Conclusion: </bold>A 3-month treatment with UPA before laparoscopy for large uterine myomas decreases intraoperative blood loss, hemoglobin drop, postoperative blood transfusion and length of surgery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03012115
- Volume :
- 205
- Database :
- Academic Search Index
- Journal :
- European Journal of Obstetrics & Gynecology & Reproductive Biology
- Publication Type :
- Academic Journal
- Accession number :
- 118341071
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2016.08.021