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Prognostic factors and adjuvant therapy on survival in early-stage cervical adenocarcinoma/adenosquamous carcinoma after primary radical surgery: A Taiwanese Gynecologic Oncology Group (TGOG) study.
- Source :
-
Surgical Oncology . Sep2016, Vol. 25 Issue 3, p229-235. 7p. - Publication Year :
- 2016
-
Abstract
- Objective: We aimed to identify prognostic factors of early-stage cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) treated with primary radical surgery, and to evaluate the impact of postoperative adjuvant therapy on outcome. Methods: The clinical-pathological data of all patients (n = 1132) with stages l-II cervical AC/ASC treated with primary radical surgery at the member hospitals of the Taiwanese Gynecologic Oncology Group were retrospectively reviewed. Results: In multivariate analysis, stage II, deep stromal invasion (DSI), lymphovascular space invasion (LVSI), positive pelvic lymph node (PLN), and parametrial involvement (PI) were significant factors for recurrence-free survival (RFS), while only DSI, PI, and positive PLN were independent factors for cancerspecific survival (CSS). Low- and high-risk groups were defined by prognostic scores derived from the four factors (DSI, LVSI, positive PLN, PI) selected by internal validation. Postoperative adjuvant therapy significantly improved outcome for PLN-positive patients (RFS, p = 0.014; CSS, p = 0.016), but not for PLN-negative high-risk group because of higher mean prognostic score (p = 0.028) of adjuvant+ than adjuvant-patients. Conclusions: PLN metastasis, PI, DSI, and LVSI were independent prognostic factors. Prospective studies of postoperative adjuvant therapy with prognostic score and nodal status stratification for cervical AC/ ASC are necessary. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09607404
- Volume :
- 25
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 118412331
- Full Text :
- https://doi.org/10.1016/j.suronc.2016.05.028