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Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort.

Authors :
Krams, Thomas
Ruyssen-Witrand, Adeline
Nigon, Delphine
Degboe, Yannick
Tobon, Gabriel
Fautrel, Bruno
Berenbaum, Francis
Cantagrel, Alain
Constantin, Arnaud
Source :
Joint Bone Spine. Oct2016, Vol. 83 Issue 5, p511-515. 5p.
Publication Year :
2016

Abstract

<bold>Objectives: </bold>To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.<bold>Methods: </bold>The ESPOIR cohort is a multicenter cohort of patients with early arthritis. We selected patients fulfilling the 2010 ACR/EULAR criteria for RA during the first 3years of follow-up. Patients were pooled into 3 groups by age at RA onset: <45years (young-onset RA [YORA]), 45 to 60years (intermediate-onset RA [IORA]) and>60years (late-onset RA [LORA]). The following outcomes were compared at baseline and during the first 3years of follow-up: Simple Disease Activity Index (SDAI) remission rate, one additional erosion, Health Assessment Questionnaire Disability Index (HAQ-DI)<0.5 and first disease-modifying anti-rheumatic drug (DMARD) continuation rate.<bold>Results: </bold>We included 698 patients (median [interquartile range] age 50.3 [39.8-57.2]years), 266 YORA, 314 IORA, and 118 LORA. At 1year, SDAI remission was greater for YORA than IORA and LORA (P<0.0001). Having at least one additional erosion was greater for LORA and IORA than YORA after 1year (P=0.009) and 3years (P=0.017). The proportion of patients with HAQ score<0.5 was greater for YORA than IORA and LORA at 1 (P=0.007), 2 and 3years. First DMARD continuation rate was lower for YORA than other groups during the 3years (P=0.005).<bold>Conclusions: </bold>In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1year, no radiographic progression at 3years and low functional score during 3-year follow-up. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1297319X
Volume :
83
Issue :
5
Database :
Academic Search Index
Journal :
Joint Bone Spine
Publication Type :
Academic Journal
Accession number :
118470338
Full Text :
https://doi.org/10.1016/j.jbspin.2015.09.010