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Chronic rhein treatment improves recognition memory in high-fat diet-induced obese male mice.
- Source :
-
Journal of Nutritional Biochemistry . Oct2016, Vol. 36, p42-50. 9p. - Publication Year :
- 2016
-
Abstract
- High-fat (HF) diet modulates gut microbiota and increases plasma concentration of lipopolysaccharide (LPS) which is associated with obesity and its related low-grade inflammation and cognitive decline. Rhein is the main ingredient of the rhubarb plant which has been used as an anti-inflammatory agent for several millennia. However, the potential effects of rhein against HF diet-induced obesity and its associated alteration of gut microbiota, inflammation and cognitive decline have not been studied. In this study, C57BL/6J male mice were fed an HF diet for 8 weeks to induce obesity, and then treated with oral rhein (120 mg/kg body weight/day in HF diet) for a further 6 weeks. Chronic rhein treatment prevented the HF diet-induced recognition memory impairment assessed by the novel object recognition test, neuroinflammation and brain-derived neurotrophic factor (BDNF) deficits in the perirhinal cortex. Furthermore, rhein inhibited the HF diet-induced increased plasma LPS level and the proinflammatory macrophage accumulation in the colon and alteration of microbiota, including decreasing Bacteroides-Prevotella spp. and Desulfovibrios spp. DNA and increasing Bifidobacterium spp. and Lactobacillus spp. DNA. Moreover, rhein also reduced body weight and improved glucose tolerance in HF diet-induced obese mice. In conclusion, rhein improved recognition memory and prevented obesity in mice on a chronic HF diet. These beneficial effects occur via the modulation of microbiota, hypoendotoxinemia, inhibition of macrophage accumulation, anti-neuroinflammation and the improvement of BDNF expression. Therefore, supplementation with rhein-enriched food or herbal medicine could be beneficial as a preventive strategy for chronic HF diet-induced cognitive decline, microbiota alteration and neuroinflammation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIGH-fat diet
*RECOGNITION (Psychology)
*LIPOPOLYSACCHARIDES
*GUT microbiome
*COGNITION disorders
*LABORATORY mice
*PSYCHOLOGY
*NONSTEROIDAL anti-inflammatory agents
*REDUCING diets
*GASTROINTESTINAL agents
*ANTIOBESITY agents
*NOOTROPIC agents
*QUINONE
*ENDOTOXEMIA prevention
*COLON microbiology
*ANIMAL experimentation
*COLON (Anatomy)
*DEGENERATION (Pathology)
*DIET
*DIETARY supplements
*INTESTINAL mucosa
*MEMORY disorders
*MICE
*NERVE tissue proteins
*NEURITIS
*NEURONS
*OBESITY
*ENDOTOXEMIA
*GLUCOSE intolerance
*PREVENTION
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09552863
- Volume :
- 36
- Database :
- Academic Search Index
- Journal :
- Journal of Nutritional Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 118499777
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2016.07.008