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Identification of indicators of efficacy of the kampo formulation unkeito for cold syndrome, using a patient-based questionnaire database.
- Source :
-
Traditional & Kampo Medicine . Oct2016, Vol. 3 Issue 2, p123-128. 6p. - Publication Year :
- 2016
-
Abstract
- ABSTRACT Aim Coldness is a common complaint in kampo medicine, and is commonly treated with unkeito, but recommended indications (so-called Kuketsu) are inconsistent. The aim of the present study was therefore to identify a set of self-reported symptoms that would predict a positive outcome of treatment for coldness with unkeito, and that would therefore serve as specific indications for treatment with unkeito. Methods This was a retrospective cohort study of 70 female patients (median age, 33 years; range, 22-71 years) without organic abnormalities who complained of coldness, and who completed a self-report questionnaire about their health using the present kampo questionnaire database system on their first visit. Another 26 female patients (median age, 38 years; range, 22-60 years) were assigned to verify the discriminatory predictive ability of the developed logit model. Patients were treated with two or three packages of unkeito per day for 1 month, and the efficacy of treatment was then recorded as a binary response. Results Unkeito decreased frequency and severity scales (0-4) of coldness from a median of 3.0 (range, 1-4) to 2.0 (range, 0-4; P < 0.001) and from 3.0 (range, 2-4) to 2.0 (range, 0-4; P < 0.001), respectively. Both frequency and severity of coldness were improved in 77.1% of patients. The developed model for prediction of treatment effect consisted of dry lips ( Akaike information criterion ( AIC), −14.10), with coldness in the feet ( AIC, −25.01) but not in the whole body ( AIC, −25.01). Model validation with 26 new patients gave a predictive accuracy of 77%. Conclusion Dry lips, accompanied by coldness in the feet, but not in the whole body, are important indications for treatment with unkeito. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20534515
- Volume :
- 3
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Traditional & Kampo Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 118554260
- Full Text :
- https://doi.org/10.1002/tkm2.1050