原发性骨质疏松症 PRO 量表的科学性考核.

Objective To evaluate the scientific quality of the patient-reported outcome instrument for primary osteoporosis. Methods We retested 52 primary osteoporosis patients and 92 healthy volunteers to evaluate the difficulty, discrimination, reliability, validity and feasibility of the OPPRO instrument by using the classical test theory and modern item response theory methods. Results The IRT analysis showed that the difficulty and discrimination of the OPPRO instrument are within acceptable parameters. For reliability, the Cronbach's coefficient of the whole instrument is 0. 801, the coefficient of the main symptoms aspect of the instrument is 0. 907, the systemic performance aspect 0. 780, the psychological aspect 0. 849, the social aspect 0. 807, the performance in daily activities aspect 0. 799,and the performance satisfaction aspect 0. 877. All of these results represented a good internal consistency of the instrument. The Pearson correlation coefficient of the retest reliability of the instrument is 0. 925, the Kendall correlation coefficient is 0. 759, both of them suggests a good retest reliability. For validity, the structural validity of the results indicates that the multidimensional structure of the instrument meets to our professional expectations. For the feasibility analysis,the sampling survey of the primary osteoporosis patients showed that the total completion rate of the instrument is 90. 34% and the time required to complete is about 15 minutes. Conclusion By using the classical statistical testing and the item response theory to analyze the items of the patient-reported outcomes of primary osteoporosis, we found that the OPPR instrument has good difficulty, discrimination, reliability, validity and feasibility. The study was conducted strictly in standard steps and took consideration of Chinese culture. The scope of the research, the methodology and the reporting methods are of a high quality, which represents good innovation, scientific quality and as well as clinical significance. The OPPRO is a useful tool for evaluating the clinical outcomes in patients with primary osteoporosis. [ABSTRACT FROM AUTHOR]