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Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic patients.
- Source :
-
Psychiatry Research . Nov2016, Vol. 245, p116-118. 3p. - Publication Year :
- 2016
-
Abstract
- Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits and repetitive behaviors with restricted interests. A previous quantitative proteomic profiling study demonstrated that microtubule-associated stable tubule only polypeptide (STOP; also known as MAP6) protein was significant reduced in the cerebral cortex from BTBR mouse model of autism compared to the C57BL/6J mice. In the present study, the result showed that the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls. Finally, a possible mechanism of STOP/MAP6 protein in the pathogenesis of autism was proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01651781
- Volume :
- 245
- Database :
- Academic Search Index
- Journal :
- Psychiatry Research
- Publication Type :
- Academic Journal
- Accession number :
- 118739271
- Full Text :
- https://doi.org/10.1016/j.psychres.2016.08.024