Back to Search
Start Over
Trajectories of function and biomarkers with age: the CHS All Stars Study.
- Source :
-
International Journal of Epidemiology . Aug2016, Vol. 45 Issue 4, p1135-1145. 11p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.<bold>Methods: </bold>We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.<bold>Results: </bold>Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.<bold>Conclusions: </bold>Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMORBIDITY
*BIOMARKERS
*PHYSICAL activity
*MILD cognitive impairment
*SEX hormones
*AGING
*COGNITION
*GAIT in humans
*GRIP strength
*HEALTH status indicators
*INTERLEUKINS
*LONGITUDINAL method
*NEUROPSYCHOLOGICAL tests
*PROTEINS
*PSYCHOLOGICAL tests
*RESEARCH funding
*SOMATOMEDIN
*ACTIVITIES of daily living
*ADIPONECTIN
Subjects
Details
- Language :
- English
- ISSN :
- 03005771
- Volume :
- 45
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 118741050
- Full Text :
- https://doi.org/10.1093/ije/dyw092