Back to Search
Start Over
Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma.
- Source :
-
Biomarkers . Sep2016, Vol. 21 Issue 6, p517-522. 6p. - Publication Year :
- 2016
-
Abstract
- We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 21
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 118837304
- Full Text :
- https://doi.org/10.3109/1354750X.2016.1160291