Review on Non-Invasive Diagnosis of Pancreatic Cancer.

The pancreatic cancer has the worst prognosis among gastrointestinal cancers, with a mortality rate close to incidence. The analysis on the globe carried out by GLOBOCAN in 2012 places the pancreatic cancer on the 13th place in terms of incidence and on the 8th place in terms of mortality of all cancers and in relation with digestive cancers it occupies the 6th place for both epidemiological indices. The high mortality is justifi ed by the paucity of symptoms, since it becomes clinically manifest upon the onset of secondary determinations and the lack of response to treatment. 80-85% of the patients come in the stage of non-resecability. The lack of sensitive tumoral markers specifi c to the early diagnosis of the pancreatic cancer has a major contribution to the poor prognosis. The goal of this article is to present all the discoveries that have been made so far in the fi eld of biomarkers involved in the pancreatic cancer, namely CEA carcinoembryonic antigen, CA19-9 antigen and microRNA. [ABSTRACT FROM AUTHOR]