Prognostic value of the combination of serum l -kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia.

Authors :: Hara, Takeshi
Matsumoto, Takuro
Shibata, Yuhei
Nakamura, Nobuhiko
Nakamura, Hiroshi
Ninomiya, Soranobu
Kitagawa, Junichi
Nannya, Yasuhito
Shimizu, Masahito
Ito, Hiroyasu
Saito, Kuniaki
Tsurumi, Hisashi
Source :: Leukemia & Lymphoma. Sep2016, Vol. 57 Issue 9, p2208-2211. 4p.
Publication Year :: 2016
Abstract: The article discusses the prognostic value of serum L-kynurenine (KYN) level combined with indoleamine 2,3-dioxygenase (IDO) mRNA expression in acute myeloid leukemia. Assessments performed include high-performance liquid chromatography, polymerase chain reaction for IDO mRNA expression analysis, and KYN pathway. The study concludes the useful combination of serum KYN concentration and IDO mRNA expression than either factor when considering the indications in AML patients.

Subjects :: *INDOLEAMINE 2,3-dioxygenase
*KYNURENINE
*MESSENGER RNA
*GENE expression
*ACUTE myeloid leukemia
*POLYMERASE chain reaction
*GENETICS

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