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Activin A Stimulates Aromatase via the ALK4-Smad Pathway in Endometriosis.
- Source :
-
BioMed Research International . 10/19/2016, Vol. 2016, p1-10. 10p. - Publication Year :
- 2016
-
Abstract
- Endometriosis is an estrogen-dependent disease. We previously found that the expression of Activin A was upregulated in the peritoneal fluid of patients with endometriosis. The results of the present study indicated that Activin A induced estradiol secretion and P450arom expression in endometrial stromal cells (ESCs) derived from endometriosis patients. The mechanism of estrogenic synthesis was regulated by the Activin-Smad pathway in endometrial lesions. The data showed that the effect of Activin A on ESCs was partially abrogated by pretreatment with an inhibitor of ALK4 (the type I receptor, ActRIB) and Smad4-siRNA. Cumulatively, these data suggest that Activin A promotes the secretion of estradiol from ESCs by increasing the expression of P450arom via the ALK4-Smad pathway. These findings indicate the ALK4-Smad pathway may promote ectopic lesion survival and development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIAGNOSIS of endometriosis
*RNA physiology
*ANALYSIS of variance
*BLOOD circulation
*ENDOMETRIOSIS
*ESTRADIOL
*ESTROGEN
*GENE expression
*GROWTH factors
*GYNECOLOGY
*LAPAROSCOPY
*MEDICAL care
*PATIENTS
*POLYMERASE chain reaction
*PROTEINS
*RESEARCH funding
*SURVIVAL
*WESTERN immunoblotting
*DATA analysis software
*SIGNAL peptides
*DESCRIPTIVE statistics
*CYTOCHROME P-450
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 118903480
- Full Text :
- https://doi.org/10.1155/2016/5791510