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Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis.
- Source :
-
Cancer Letters . Dec2016, Vol. 383 Issue 1, p53-61. 9p. - Publication Year :
- 2016
-
Abstract
- Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2- and Ag-NPs. Sun-protection-factor calculated based on their UVB-reflective/absorption abilities was the highest for TiO2-NPs followed by Ag- and ZnO-NPs. This was further confirmed by studying indirect protection of UVB radiation-induced death of HaCaT cells. However, only Ag-NPs were active in protecting HaCaT cells against direct UVB-induced DNA-damage by repairing bulky-DNA lesions through nucleotide-excision-repair mechanism. Moreover, Ag-NPs were also effective in protecting HaCaT cells from UVB-induced oxidative DNA damage by enhancing SOD/CAT/GPx activity. In contrast, ZnO- and TiO2-NPs not only failed in providing any direct protection from DNA-damage, but rather enhanced oxidative DNA-damage by increasing ROS production. Together, these findings raise concerns about safety of ZnO- and TiO2-NPs and establish superior protective efficacy of Ag-NPs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SKIN cancer prevention
*DNA damage
*TITANIUM dioxide nanoparticles
*ZINC oxide
*SILVER
*COMPARATIVE studies
*THERAPEUTICS
*REACTIVE oxygen species
*ANTINEOPLASTIC agents
*ANTIOXIDANTS
*CELL death
*CELL lines
*DNA
*DOSE-effect relationship in pharmacology
*KERATINOCYTES
*RESEARCH methodology
*MEDICAL cooperation
*METALS
*OXIDOREDUCTASES
*RESEARCH
*SILVER compounds
*SKIN tumors
*SUNSCREENS (Cosmetics)
*SUPEROXIDE dismutase
*TITANIUM
*ULTRAVIOLET radiation
*SUNBURN
*OXIDATIVE stress
*EVALUATION research
*PHARMACODYNAMICS
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 383
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 119095673
- Full Text :
- https://doi.org/10.1016/j.canlet.2016.09.026