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Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein.
- Source :
-
Journal of Neuroimmunology . Nov2016, Vol. 300, p66-73. 8p. - Publication Year :
- 2016
-
Abstract
- Previous work demonstrated that EAE induced by recombinant human MOG was B cell-dependent. Data presented here reveal a T cell response to MOG61–85 in human rMOG-immunized B cell −/− mice not observed in WT mice. Further study revealed this peptide to be a cryptic epitope in WT mice. Co-immunization of B cell −/− mice with MOG35–55 and MOG61–85 peptides led to less severe disease compared to mice immunized with MOG35–55 alone. Disease amelioration was associated with decreased production of Interferon-γ by lymph node cells. Thus, MOG61–85 represents a protective epitope to human rMOG induced EAE in B cell −/− mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 300
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 119155581
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2016.06.006