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Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains.
- Source :
-
Journal of Infectious Diseases . 11/15/2016, Vol. 214 Issue 10, p1477-1486. 10p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Influenza viruses gradually accumulate point mutations, reducing the effectiveness of prior immune protection.<bold>Methods: </bold>Children aged 9-14 years received 2010-2011 trivalent inactivated influenza vaccine (TIV). Vaccination history, hemagglutination-inhibition (HI) titers, and cell-mediated immune responses were assessed to investigate the cross-reactivity with past and future influenza virus strains.<bold>Results: </bold>2010-2011 TIV induced significant T-cell responses and HI titers of ≥160, with a fold-rise of ≥4 and titers of ≥100 maintained for >7 months in the majority of children. Pre-existing memory B cells in these children differentiated quickly to antibody-secreting cells to the new vaccine antigens. Children vaccinated in the previous year maintained high HI titers well into 2010, demonstrating elevated HI titers against A/Perth/16/2009, the future (in 2010-2011) H3N2 component. Prior vaccination enhanced CD8+ T-cell responses to A/Perth/16/2009. Children vaccinated with the prior 2009-2010 seasonal vaccine also demonstrated higher preexisting levels of interferon γ-secreting CD4+CD69+ T cells to 2009 pandemic influenza A(H1N1). Children previously vaccinated with 2009-2010 seasonal influenza vaccine also showed greater expansion of tumor necrosis factor α-secreting CD8+CD69+ T cells to 2009 pandemic influenza A(H1N1) upon vaccination in the 2010-2011 season than those who were not previously vaccinated.<bold>Conclusions: </bold>Seasonal influenza viruses continuously drift, which allows them to circumvent protective immunity, but conserved epitopes provide immunological cross-reactivity in children through either vaccination directly or through prime/boost in the prior influenza season. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SEASONAL influenza
*VACCINATION of children
*IMMUNE response
*TUMOR necrosis factors
*BLOOD agglutination
*VACCINATION
*INFLUENZA prevention
*ANTIGEN-antibody reactions
*CELLULAR immunity
*HEMAGGLUTINATION tests
*INFLUENZA
*INFLUENZA vaccines
*ORTHOMYXOVIRUSES
*T cells
*TIME
*VACCINES
*VIRAL antibodies
*ANTIBODY formation
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 214
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 119163634
- Full Text :
- https://doi.org/10.1093/infdis/jiw380