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Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma.
- Source :
-
BioMed Research International . 11/8/2016, Vol. 2016, p1-9. 9p. - Publication Year :
- 2016
-
Abstract
- Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression. It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer. This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression. RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors. lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression. Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/β-catenin pathway in part. Our study suggests that lncRNA-LET exhibits an important tumor-suppressive effect on LAC progression by inhibiting EMT and Wnt/β-catenin pathway, which provides potential therapeutic targets for LAC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADENOCARCINOMA
*EPITHELIUM
*RNA physiology
*BIOLOGICAL assay
*CELL culture
*CELL migration
*DYES & dyeing
*GENE expression
*IMMUNOHISTOCHEMISTRY
*MICROBIOLOGICAL assay
*LUNG tumors
*POLYMERASE chain reaction
*RESEARCH funding
*TRANSFER RNA
*WESTERN immunoblotting
*WOUND healing
*DATA analysis
*DISEASE progression
*DATA analysis software
*DIAGNOSIS
*PREVENTION
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 119323792
- Full Text :
- https://doi.org/10.1155/2016/4693471