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The application of graphene for in vitro and in vivo electrochemical biosensing.

Authors :
Janegitz, Bruno Campos
Silva, Tiago Almeida
Wong, Ademar
Ribovski, Laís
Vicentini, Fernando Campanhã
Taboada Sotomayor, Maria del Pilar
Fatibello-Filho, Orlando
Source :
Biosensors & Bioelectronics. Mar2017 Part 1, Vol. 89, p224-233. 10p.
Publication Year :
2017

Abstract

Advances in analysis are required for rapid and reliable clinical diagnosis. Graphene is a 2D material that has been extensively used in the development of devices for the medical proposes due to properties such as an elevated surface area and excellent electrical conductivity. On the other hand, architectures have been designed with the incorporation of different biological recognition elements such as antibodies/antigens and DNA probes for the proposition of immunosensors and genosensors. This field presents a great progress in the last few years, which have opened up a wide range of applications. Here, we highlight a rather comprehensive overview of the interesting properties of graphene for in vitro , in vivo, and point-of-care electrochemical biosensing. In the course of the paper, we first introduce graphene, electroanalytical methods (potentiometry, voltammetry, amperometry and electrochemical impedance spectroscopy) followed by an overview of the prospects and possible applications of this material in electrochemical biosensors. In this context, we discuss some relevant trends including the monitoring of multiple biomarkers for cancer diagnostic, implantable devices for in vivo sensing and, development of point-of-care devices to real-time diagnostics. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09565663
Volume :
89
Database :
Academic Search Index
Journal :
Biosensors & Bioelectronics
Publication Type :
Academic Journal
Accession number :
119341347
Full Text :
https://doi.org/10.1016/j.bios.2016.03.026